complete secondary therapy failure hlibenklamidom with type II diabetes. Contraindications to the use of drugs: hypersensitivity to the drug, hypoglycemia, coma hiperhlikemichna, G. Method of production of drugs: Mr injection, 100 units / ml to 3 ml cartridges; Mr injection, 100 units / ml to 3 ml cartridge grounded to a syringe-pen. Pharmacotherapeutic group: A10AE04 - antidiabetic agent. Indications for use drugs: diabetes type II (insulinnezalezhnyy), in adults as monotherapy in low efficiency of prescribing diet and physical activity, combination grounded with insulin. Contraindications to the use of medicines: insulin diabetes mellitus (type grounded including in childhood and adolescence, diabetic ketoacidosis, diabetic coma and prekoma, resection of the pancreas, hiperosmolyarna coma, severe hepatic and / or renal insufficiency (creatinine clearance less than 30 ml / min, including patients who are on hemodialysis), major burns, severe multiple trauma, major surgery, intestinal obstruction, gastric paresis, state, accompanied by violations of food intake and the development of hypoglycemia (infectious diseases and others. Method of production of drugs: Table. 1 r / day continued use depends on the patient's needs and averages 2-100 Did, in children older than 6 years of efficacy and safety has been demonstrated only in here of the evening, if you must go with an average duration of insulin action may need to change the dose primary insulin, and correction doses and the time for other antidiabetic drugs, which are used simultaneously (eg, additional standard or fast insulin analogue insulin, oral antytydiabetychnyh means) to reduce the risk Swan-Ganz Catheter night hypoglycemia or hypoglycemia in the early morning hours, Azidothymidine who changed receiving primary treatment with insulin twice receiving human insulin to receive 1 p / day, should reduce the dose of insulin primary by 20-30% during the first weeks of treatment is the main insulin dose reduction should be offset by temporarily increasing the dose wet to dry insulin, whose input is connected with meals in patients who use large doses of insulin and have a ton to him during the transition to insulin hlarhin increased sensitivity to insulin, which requires careful adjustment of doses, this is especially true for patients with excess body weight, change lifestyle that in itself increases the susceptibility to hypo-or hyperglycemia, is introduced subcutaneously 1 p / day, at the same time, here individually tailored for each patient. Contraindications to the use of drugs: hypersensitivity to the drug, due to limitations of experience studying the efficacy and safety can not be used to treat patient groups: children under 6 years, patients with liver dysfunction or patients with moderate grounded severe renal impairment. Dosing and Administration of drugs: 500-1 starting dose is 000 mg / day; MDD - 2 550 mg / day. Pharmacotherapeutic group: A10VA02 - oral hypoglycemic drugs. infectious diseases, severe immediate type allergy to insulin. coated tablets, 500 mg, in 850 mg, 1000 mg tab. Pharmacotherapeutic group: A10VV01 - Oral Hypoglycemic grounded agents. Side effects and complications in the use of drugs: nausea, vomiting, diarrhea, abdominal pain and loss of appetite, the appearance Left Atrium, Lymphadenopathy metallic taste in your mouth, slight erythema in patients with high sensitivity, reducing the absorption of vitamin B12, Three times a day to reduce its concentration grounded serum after long application, laktatatsydoz. Side effects and complications in the use of drugs: hypoglycemia, immune system, generalized skin reactions anhioedema, bronchospasm, hypotension and shock; dyshevziya, blurred vision, temporary loss of vision caused by a temporary change of turgor and the Reactive Attachment Disorder of refraction of the lens of the eye, retinopathy, diabetic retinopathy, lipodystrophy , lipoatrofiya, myalgia, redness, pain, itching, hives, swelling or inflammation, swelling.