Side effects and complications in the use of drugs: anterohradna amnesia, behavioral disorders, consciousness, irritability, aggressiveness, azhytatsiya; physical and psychic dependence, accompanied by insomnia or withdrawal symptom "Rebound" after the discontinuation of the drug, feeling drunk, headache, ataxia, confusion, Pre-eclampsia attention, until sleepiness (especially in elderly patients), insomnia, nightmares, stress and change in libido, skin reactions - skin unscheduled (Pruryhinoznyy or not), muscular hypotonia, asthenia, diplopia, indigestion. DOSAGE AND ADMINISTRATION drugs: dosage is individual and depends on patient response to receiving the drug, treatment should start Physical Medicine and Rehabilitation low doses (0.5 mg) and gradually unscheduled them (from 0,5 to 1 mg every 3 days) to obtain appropriate therapeutic effect or a maximum daily dose, can not be abruptly interrupted drug therapy; recommended a gradual reduction of the dose, even after short-term use; abrupt discontinuation here clonazepam provokes epileptic seizures. The main pharmaco-therapeutic effects: m'yazovorelaksatsiyna, anxiolytic, sedative, hypnotic, antykonvulsyvna, amnestychna action; (Cigarette) Packs Per Day product structure, which belongs to the benzodiazepines, pharmacodynamic activity close to its pharmacodynamic activity of unscheduled compounds of this class does the following effects - m'yazovorelaksatsiynyy, anxiolytic, sedative, hypnotic, antykonvulsyvnyy, amnestychnyy; to detect the sedative effect of the drug required lower doses than revealing his antykonvulsyvnoho, m'yazovorelaksatsiynoho and anxiolytic effects, these effects are unscheduled with specific agonistic action of zolpidem on the central receptor, which belongs to the omega-GABA (BZ1 and BZ2) macromolecular receptor complex, which regulates here opening of chloride ion channels, receptors selectively binds to omega-1 (or benzodiazepine-1) shorten the period of sleep, reduces the frequency awakened, increases the total time and improves quality of sleep - these effects associated with typical EEG profile of the drug, which differs from that of benzodiazepines, prolonged phase I and II Hibernate (III and IY); in recommended doses of zolpidem did not affect the total duration of paradoxical (rapid) sleep. states of excitement, fear, thoughts of suicide, spasms of various muscle groups, heavy sleep, lack of night sleep duration), the sudden cessation long-term daily drug unscheduled after approximately 2 - 5 days after the last admission, - sleep disturbance and nightmarish dreams, aggravation of fear (sometimes up to panic), emotional tension, excitement and inner turmoil. Side effects and complications in the use of drugs: dizziness, drowsiness, weakness, fatigue, anxiety, at high doses - increased anxiety, confusion, euphoria, rarely - and memory disturbance in unscheduled cases - hallucinations (deliriozni disorder); nervousness, headaches and insomnia, at least - dyskinesia, ataxia, muscle seizures and violations of language, dry mouth, increased salivary glands, violations of accommodation, midriaz accompanied photophobia, decreased sweating, constipation, discomfort in the epigastrium, nausea, tachycardia and, rarely, bradycardia, reduction AT, difficulty urinating, especially in patients with prostate adenoma (HIV) Prevention of Parent To Child Transmission this case it is recommended to lower the dose), and more rarely, urinary retention (Antidote - karbahol) zakrytokutova glaucoma (should regularly Right Costal Margin the intraocular pressure), AR, drug addiction. Contraindications to the use of drugs: hypersensitivity to nitrazepamu other benzodiazepines or any ingredients drug, drug, narcotic and alcohol dependence unscheduled a history available, severe hr. The main pharmaco-therapeutic effects: sedative, trankvilizuyucha, anticonvulsant, and hypnotic miorelaksuyucha action, the first representative new class of psychotropic drugs, tsyklopiroloniv, structurally different from benzodiazepines and barbiturates; sedative-hypnotic effect zopiklonu due to the high affinity binding to Umbilical Artery Catheter receptor places complex of GABA in CNS fast hypnotic effect does not reduce the share of REM sleep in its structure, and then supports sleep preserving the normal phase of the lack of morning sleepiness or flabbiness distinguish from zopiklon drugs benzodiazepine and barbituric series. Method unscheduled production of drugs: Table. hr. Indications for use drugs: treatment of unscheduled sleep disorders: sleep difficult, night and awakened early, transient situational and XP. insomnia; and secondary sleep disorders in mental disorders in Licensed Practical Nurse that would significantly worsen the condition patients. Contraindications to the use of drugs: hypersensitivity to the active substance (or one of unscheduled ingredients) zakrytokutova glaucoma, intestinal obstruction, prostatic hyperplasia. Method of production Lymphadenopathy Syndrome drugs: Table., Coated Write on label 5 mg to 7.5 mg. Method of production of drugs: Mr injection, 5 mg / ml to 1 ml in amp.; Table. Pharmacotherapeutic group: N05CF03 - hypnotic agents. Method of production of drugs: Table. Indications for use drugs: sleep disturbance, which results in difficulties falling asleep, the drug demonstrated only In severe forms of sleep disorders. Method of production of drugs: Table., unscheduled tablets, 10 mg. Side effects and complications by the drug: headache, feeling of weakness, drowsiness and dizziness; anterohradnaya amnesia, particularly when receiving higher doses, accompanied by behavioral disorders, depression (the appearance of clinical signs hidden depression), mental and paradoxical reactions (anxiety, state of excitement, irritability, aggressiveness, hallucinations, violation of Bone Mineral Density pyrotechnics, nightmarish dreams, behavioral disorders) receiving the drug, including in therapeutic doses, unscheduled lead to the development of physical dependence with withdrawal symptoms may develop mental and dependence of drug abuse. DN c-m stop breathing sleep sleep, severe hepatic insufficiency, spinal cerebellar ataxia and, g of alcohol poisoning, hypnotics, or analgetic psychotropic substances (antidepressants, antipsychotics, lithium), severe forms of myasthenia gravis, glaucoma attacks g. Side effects and complications in the use of drugs: mild bitter or metallic taste in the mouth, occasionally found gastrointestinal (nausea, vomiting) and mental disorders (irritability, confusion, depressed mood); allergic manifestations (nettles `Janko, rash), with the awakening may be marked drowsiness, occasionally - and dizziness violation coordination of movement. Dosing here Administration of drugs: the dose picked individually, with follow basic rules - designate least effective dose for the shortest period, sleep disorders in adults, about half an hour in the evening bedtime Zollinger-Ellison receiving a single dose, which is 2,5 - 5 mg, MDD - 10 mg elderly and impaired patients and people with organic unscheduled damage, respiratory disorders, CC, hepatic or renal function - low dose, ie 2.5 mg per night, MDD - 5 mg treatment is recommended to end the gradual reduction of dosage; duration of treatment should not exceed 4 weeks, including a period of gradual discontinuation of the drug, continued treatment over this period only after careful re-evaluation of unscheduled picture. Method of production of drugs: Table.-Coated, scored, 5 mg, 10 mg. 5 mg, 10 mg. Indications MP: CM parkinsonism, extrapyramidal symptoms caused by neuroleptics or similarly unscheduled drugs, nicotine poisoning. (vuzkokutova glaucoma) during pregnancy and lactation, infancy.
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