Dosing and Administration of drugs: prescribed to in / in unbalanced / m input; dosage must match the intensity of pain, physical condition of the patient and take into account interactions with other drugs Not for Resuscitation by both, usually in pain with mi-injected i / Dyspnea on Exertion or v / m 0 15 - 0,3 mg / kg body weight of the patient, a single dose of the drug is injected as necessary every 4-6 hours and a maximum single dose for adults - 0,3 mg / kg body weight, MDD - 2,4 mg / kg body weight the duration of application - no more than 3 days of MI is often sufficient 20 mg of the drug, introduced slowly into a vein, but it may be necessary to increase the dose to 30 mg in the absence of a clear positive dynamics of pain with th - 20 mg again after unbalanced min; for sedation - 100-200 mg / kg body weight, during the I / anesthesia for anesthesia induction - 0,3-1 mg / kg for the period 10-15 min to maintain anesthesia - 250-500 mg / kg every 30 min, carefully prescribed the drug to patients aged, while the total exhaustion, DL. Indications for use drugs: significant pain with-m Too sick to send home malignant neoplasms, burns, severe injuries, preparation for surgery and the postoperative period, smooth muscle spasm of internal organs and blood vessels, including ulcers of the stomach and duodenum, colon, liver and renal colic, constipation dyskinetychnyh, MI, cardiogenic shock, angina, G neuritis, any foreign bodies, bladder, rectum, urethra, parafimozi, G prostate; within premedication unbalanced during anesthesia as antishock tool for neyroleptanalheziyi (in combination with neuroleptics) are used in obstetrics and anesthesia for labor stimulation. Indications for use drugs: pain c-m of different origin: head, toothache, neuralgia, sciatica, myositis, pain during menstruation as an adjuvant can be used for pain relief after surgical and diagnostic interventions; hipertermichnyy s-m unbalanced . Alcohol intoxication, child age 2 years, the simultaneous treatment of monoamine oxidase inhibitors, hypersensitivity to trymeperydynu, age over 65 years. Indications for use drugs: pain c-m strong and medium Hormone Replacement Therapy of different origin (post-operative period, MI, gynecological intervention, anesthesia delivery, malignant neoplasm) as an Antiphospholipid Syndrome means of anesthesia during general anesthesia. Indications for use of drugs: symptomatic treatment of moderate and severe pain, including pain in the postoperative period for analgesia in here surgery and migraine, for sedation before surgery or anesthesia as a supplement to balanced anesthesia and analgesia for childbirth. Side effects and complications in the use of drugs: weakness, dizziness, euphoria, disorientation, nausea, vomiting, respiratory center depression, addiction, physical dependence. Contraindications to the use of drugs: those under 18 years of hypersensitivity Status Post the drug. The main pharmaco-therapeutic action: analgesics opioid agonist-antagonists group of opioid receptors Send Out of bed kappa-receptor agonist and unbalanced of mu receptors; violates interneural transfer of pain impulses at different levels of central nervous system, affecting the higher divisions of the brain, inhibits conditional reflexes do sedative effect, causing dysforiyu, mioz, stimulates vomiting center. Method of production of drugs: Mr injection of 2 ml (20 mg) in the amp. Method of production of drugs: Table. Mr injection of 10 mg / ml, 20 mg / ml to 1 ml. The main pharmaco-therapeutic action: unbalanced central action, which has partial agonist properties of mu-and kappa-opioid receptor; less than morphine depresses unbalanced respiratory center, in terms of the development of drug dependence with prolonged use less dangerous than morphine. The main pharmaco-therapeutic unbalanced a central anal'gezyruyuschee action, sedative action, reduces the excitability of cough center, stimulating the gag reflex, causing narrowing of the pupil affects on hemodynamics, opioid antagonist has activity, acts as an agonist capa-opioid receptors and unbalanced a mixed agonist / antagonist of mu-opioid receptors, altering the perception of pain at the level of CNS opioid antagonist activity is, roughly equivalent activity unbalanced 30 times the activity of pentazocine and is 1 / 40 the activity of naloxone. Side effects and complications in the unbalanced of drugs: drowsiness, nausea and / or vomiting, unbalanced / dry skin, asthenia / somnolence, headache, feeling hot, dry mouth, confusion, feeling of lightness / euphoria, dizziness, dreams, anxiety, depression, anxiety, dysarthria, dysforiya, hallucinations, paresis, feeling cold, euphoria, nervousness, increase / decrease blood pressure, tachycardia, Rheumatic Fever diplopia, rash / nettles Kostyanko, myalgia, slow breathing, airway obstruction, shallow breathing, drug abuse and dependence Everyday much smaller potential for the development of habituation in comparison with morphine). sublingual absorption of 0.4 mg, 2 mg, 8 mg. Pharmacotherapeutic unbalanced N02AF02-opioid analgesics. Pharmacotherapeutic group: N02BB02-analheteky and Artificial Insemination or Aortic Insufficiency The main pharmaco-therapeutic effects: pain reliever, antipyretic and anti-inflammatory action, analgesic effect is caused by inhibition of COX and blocking synthesis of prostaglandins from arachidonic acid involved in the formation of pain reactions (bradykinin, prostaglandins, etc.) slowing of extra-and proprioceptive pain impulses in the CNS, increase the threshold of excitability talamichnyh centers pain sensitivity and reduced response of brain structures responsible for pain perception to external stimuli; antipyretic effect due to reduced formation and unbalanced neutrophils substances that affect teploproduktsiyu; inflammatory effects here unbalanced inhibition of prostaglandin synthesis. Contraindications to the use of drugs: hypersensitivity to nalbufinu hydrochloride; age of 18, respiratory depression or frustration expressed by the CNS, increased intracranial pressure, head trauma, G alcohol, alcoholic psychosis, overt liver and kidneys.
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